Cefixime

Cefixime, bacteria-fighting drug in a group known as cephalosporin antibiotics. It is used to treat bacterial infections in the ears, throat, chest, and urinary tract. It is also used to treat gonorrhea. Cefixime works by interfering with the invading bacteria’s ability to multiply in the body.

This drug is available by prescription in tablet and liquid form, which are both taken orally. The typical dosage for adults and children over the age of 12 is 400 mg per day, taken in one or two doses. Children over 6 months of age may take this drug safely, also in one or two daily doses. The total daily dose for children is determined by body weight.

Cefixime works fastest when taken on an empty stomach, but it may be taken with food if it otherwise causes stomach upset. Effectiveness is usually apparent after three to five days, but to prevent a recurrence of infection, the entire course of medication should be taken. However, prolonged use is not recommended, as it may lead to a secondary infection.

Patients with diabetes should be aware that cefixime may affect the accuracy of urine glucose-monitoring tests. Patients with kidney disorders or with colitis (inflamed colon) or other gastrointestinal problems should use this drug with caution. Its safety for use during pregnancy has not been determined, although it is known to appear in breast milk.

Common side effects may include indigestion, mild diarrhea, gas, nausea, or vomiting. Other side effects sometimes observed are dizziness, fever, headache, itching, skin rash, vaginitis (inflammation of vaginal tissues), hives, severe diarrhea, stomach cramps, shock, or seizures. A severe allergic reaction to cefixime may occur in patients who are sensitive to both cephalosporin antibiotics and penicillin.

This drug may interact with diarrhea medications, prolonging the diarrhea or making it more severe.